John D Imig Selected Research

Antihypertensive Agents (Antihypertensives)

1/2018	Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.
10/2015	Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
12/2014	Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
10/2014	Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.
8/2014	Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.
1/2014	Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury.
2/2013	Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
6/2012	Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
1/2012	Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension.
6/2011	Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John D Imig Research Topics

Disease

83	Hypertension (High Blood Pressure) 01/2023 - 01/2002
27	Inflammation (Inflammations) 01/2023 - 10/2007
22	Fibrosis (Cirrhosis) 01/2024 - 12/2004
14	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 05/2004
11	Albuminuria 01/2019 - 08/2004
9	Proteinuria 01/2021 - 03/2006
9	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2018 - 01/2005
8	Chronic Renal Insufficiency 03/2021 - 01/2005
7	Kidney Diseases (Kidney Disease) 01/2022 - 12/2009
7	Obesity 01/2021 - 10/2003
6	Heart Failure 08/2021 - 10/2018
6	Insulin Resistance 10/2018 - 06/2007
5	Diabetic Nephropathies (Diabetic Nephropathy) 11/2021 - 06/2007
5	Myocardial Infarction 01/2019 - 06/2012
5	Malignant Hypertension 10/2018 - 01/2011
5	Body Weight (Weight, Body) 12/2015 - 08/2004
4	Ureteral Obstruction 01/2023 - 05/2016
4	Cardiomegaly (Heart Hypertrophy) 01/2021 - 08/2007
4	Neoplasms (Cancer) 11/2020 - 10/2007
4	Type 2 Diabetes Mellitus (MODY) 10/2018 - 08/2004
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2015 - 04/2002
3	Reperfusion Injury 01/2022 - 11/2018
3	COVID-19 01/2022 - 01/2022
3	Renovascular Hypertension (Goldblatt Syndrome) 01/2016 - 01/2012
3	Stroke (Strokes) 03/2011 - 12/2005
2	Metabolic Diseases (Metabolic Disease) 01/2023 - 10/2021
2	Pneumonia (Pneumonitis) 01/2022 - 12/2018
2	Hypoxia (Hypoxemia) 01/2022 - 11/2018
2	Post-Acute COVID-19 Syndrome 01/2022 - 01/2022
2	Thromboinflammation 01/2022 - 01/2022
2	Fistula 08/2021 - 01/2019
2	Alcoholic Fatty Liver 01/2021 - 01/2019
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2020 - 07/2006
2	Diabetes Mellitus 01/2020 - 04/2002
2	Infarction (Infarctions) 11/2018 - 06/2009
2	Hyperglycemia 11/2018 - 11/2017
2	Hypertrophy 03/2015 - 02/2010

Drug/Important Bio-Agent (IBA)

35	Epoxide HydrolasesIBA 01/2023 - 02/2002
30	AcidsIBA 01/2022 - 09/2005
28	Angiotensin IIIBA 08/2021 - 01/2002
19	SaltsIBA 01/2023 - 03/2003
16	Antihypertensive Agents (Antihypertensives)IBA 01/2018 - 02/2002
16	AngiotensinsIBA 10/2017 - 01/2002
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
14	EnzymesIBA 01/2019 - 03/2003
11	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 10/2018 - 03/2003
10	CollagenIBA 01/2024 - 12/2007
10	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 01/2021 - 01/2007
9	LipidsIBA 01/2023 - 10/2007
8	Glucose (Dextrose)FDA LinkGeneric 10/2018 - 02/2006
7	ReninIBA 10/2018 - 02/2010
6	SodiumIBA 01/2023 - 01/2007
6	Arachidonic Acid (Vitamin F)IBA 01/2023 - 01/2005
6	14,15-epoxy-5,8,11-eicosatrienoic acidIBA 01/2022 - 10/2015
6	EicosanoidsIBA 10/2020 - 10/2003
6	indole-3-carbinolIBA 10/2018 - 01/2011
5	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2023 - 07/2011
5	Streptozocin (Streptozotocin)FDA Link 01/2019 - 11/2011
5	XenobioticsIBA 10/2018 - 08/2011
4	Messenger RNA (mRNA)IBA 01/2024 - 01/2019
4	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2022 - 08/2004
4	Blood Glucose (Blood Sugar)IBA 11/2021 - 08/2004
4	salicylhydroxamic acid (SHAM)IBA 01/2020 - 03/2010
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 06/2007
4	EET-BIBA 01/2019 - 11/2013
4	Epoxy Compounds (Epoxides)IBA 09/2013 - 02/2008
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2010 - 03/2006
3	Hydroxyproline (4 Hydroxyproline)IBA 01/2023 - 05/2016
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 01/2022
3	Enalapril FDA LinkGeneric 11/2021 - 02/2007
3	nephrinIBA 01/2021 - 09/2009
3	Sorafenib (BAY 43-9006)FDA Link 01/2021 - 05/2012
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 10/2007
3	Epithelial Sodium ChannelsIBA 01/2020 - 09/2013
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2011
3	ProstaglandinsIBA 09/2013 - 10/2007
3	Benzoic Acid (Potassium Benzoate)FDA Link 06/2012 - 09/2009
3	Vasoconstrictor AgentsIBA 02/2010 - 01/2002
3	Desoxycorticosterone Acetate (DOCA)FDA Link 09/2009 - 01/2008
3	Interleukin-6 (Interleukin 6)IBA 10/2008 - 03/2006
3	Cysteine (L-Cysteine)FDA Link 10/2008 - 10/2007
3	Matrix Metalloproteinases (MMPs)IBA 10/2008 - 02/2006
3	cytochrome P-450 CYP2C subfamilyIBA 03/2006 - 10/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 06/2007
2	Prostaglandin D2IBA 01/2022 - 01/2022
2	ramatrobanIBA 01/2022 - 01/2022
2	Transcription Factors (Transcription Factor)IBA 10/2021 - 01/2005
2	Substance PIBA 10/2021 - 01/2019
2	Cisplatin (Platino)FDA LinkGeneric 03/2021 - 08/2013
2	CalciumIBA 01/2021 - 09/2005
2	CytokinesIBA 01/2019 - 12/2015
2	CreatinineIBA 01/2019 - 01/2018
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2018 - 05/2012
2	Captopril (Capoten)FDA LinkGeneric 04/2016 - 05/2012
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2016 - 08/2014
2	Malondialdehyde (Propanedial)IBA 01/2016 - 08/2014
2	AndrogensIBA 03/2015 - 01/2009
2	Drinking WaterIBA 10/2014 - 01/2014

Therapy/Procedure

11	Therapeutics 10/2021 - 04/2004
4	Surgical Instruments (Clip) 10/2015 - 03/2010